008 VGLL3 is a key regulator of transcriptome changes in gender biased autoimmune conditions

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Twist1 is a key regulator of cancer-associated fibroblasts.

Cancer-associated fibroblasts (CAF) are key contributors to malignant progression, but their critical regulators remain largely unknown. In this study, we examined the role of Twist1, a central regulator of epithelial-mesenchymal transition in carcinoma cells, in the transdifferentiation of normal quiescent fibroblasts to CAF and we defined its upstream controls and downstream effectors. Primar...

متن کامل

IκBζ is a transcriptional key regulator of CCL2/MCP-1.

CCL2, also referred to as MCP-1, is critically involved in directing the migration of blood monocytes to sites of inflammation. Consequently, excessive CCL2 secretion has been linked to many inflammatory diseases, whereas a lack of expression severely impairs immune responsiveness. We demonstrate that IκBζ, an atypical IκB family member and transcriptional coactivator required for the selective...

متن کامل

Lysine acetyltransferase PCAF is a key regulator of arteriogenesis.

OBJECTIVE Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional coactivator p300-CBP-associated factor (PCAF) has histone acetylating activity and promotes transcript...

متن کامل

SHORT - ROOT is a key regulator of root development

SHORT-ROOT (SHR) is a well characterised regulator of radial patterning and indeterminacy of the Arabidopsis primary root. However, its role during the elaboration of root system architecture (RSA) remains unclear. We report that the indeterminate wild-type Arabidopsis root system was transformed into a determinate root system in the short-root (shr) mutant when growing in soil or agar. The roo...

متن کامل

MDA-9/syntenin is a key regulator of glioma pathogenesis.

BACKGROUND The extraordinary invasiveness of human glioblastoma multiforme (GBM) contributes to treatment failure and the grim prognosis of patients diagnosed with this tumor. Consequently, it is imperative to define further the cellular mechanisms that control GBM invasion and identify promising novel therapeutic targets. Melanoma differentiation associated gene-9 (MDA-9/syntenin) is a highly ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2017

ISSN: 0022-202X

DOI: 10.1016/j.jid.2017.02.021